The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health: We’ve Used GLP-1s for 3 Years: What Worked, What Backfired, and What Women Need to Know

We’ve Used GLP-1s for 3 Years: What Worked, What Backfired, and What Women Need to Know

Apr 25, 2026

Three years ago, GLP-1 peptides were barely being talked about in the midlife women’s health space. Since then, Jessica and I have personally used them, experimented with different approaches, and helped over a thousand women inside our peptide program navigate what works, what backfires, and what women in perimenopause and menopause need to know before jumping in.

In this episode, we’re pulling back the curtain on our own GLP-1 journeys, including my rough start with Ozempic, why Tirzepatide worked better for me, Jessica’s experience with Semaglutide and fatigue, and why Retatrutide is becoming one of the most talked-about peptides right now. We also get into one of the biggest myths floating around online: that GLP-1s automatically cause massive muscle loss. The truth is much more nuanced.

We talk about the biggest mistakes we see women making. How Glp1s can impact insulin sensitivity, inflammation, fat cell biology, blood sugar regulation, liver metabolism, and even brain reward pathways.

We also dive into some of the peptides we’re loving right now beyond GLP-1s, including NAD, KPV, MOTS-c, and Tesamorelin, and why peptide therapy can be powerful when it’s used intelligently, not recklessly. This is a real, honest conversation about how to use these tools in a way that supports long-term health, metabolism, muscle, and hormones, instead of chasing fast weight loss at any cost.

In this episode, we cover:

Our personal three-year journey using GLP-1 peptides
Why Ozempic, Semaglutide, Tirzepatide, and Retatrutide can feel very different
The truth about GLP-1s and muscle loss
Why appetite suppression is not the only sign a GLP-1 is working
The biggest mistakes women make with dosing and titration
Why protein, amino acids, digestion, and strength training matter so much
How GLP-1s may support insulin sensitivity, inflammation, blood sugar, and metabolic health
Why some women don’t lose weight until thyroid, hormones, food sensitivities, or inflammation are addressed
What we’re seeing with Retatrutide and why it’s getting so much attention
Peptides beyond GLP-1s, including NAD, KPV, MOTS-c, and Tesamorelin

Who This Episode Is For

This episode is for women in perimenopause or menopause who are using GLP-1s, thinking about starting them, or wondering why they are not getting the results they expected.

It is especially helpful if you are worried about muscle loss, hair shedding, fatigue, dosing, long-term use, maintenance, or whether peptides are actually supporting your metabolism or just helping you eat less.